Dong Xie, Ph.D.
Associate Professor, Department of Biomedical Engineering
Associate Professor, Department of Surgery, School of Medicine
723 W. Michigan St. SL 220E
Indianapolis, IN 46202
Ph.D. Polymeric Biomaterials/Oral Biology, Ohio State University (1998)
Department of Chemistry, University of Alabama at Birmingham (1998-1999)
Advanced biomaterials for dental restoratives and orthopedics; Biodegradable polymers for tissue engineering; Functional polymers for surface modification; Polymers for regenerative medicine
Dr. Xie works primarily in the area of advanced polymeric biomaterials. One major goal in this emerging field is to develop novel polymers and their composites for dental and orthopedic applications, which include hard tissue and soft tissue restorations. The second main goal in this field is to develop novel biodegradable polymer and composite systems for tissue engineering, which includes design and formulation of deliverable, in situ polymerizable and resorbable polymers as tissue scaffolds for soft and hard tissue regenerations. The third goal is to develop functional polymers for regenerative medicine, specifically in the area of immune protection of cell or organ transplantations. He initiated collaboration with surgeons at Indiana University Medical Center on pancreatic islet transplantations. The goal of this research is to engineer tissue compatible polymers to pancreatic islets to completely diminish all the detrimental immune and complement-mediated reactions that may occur during islet allo- or xenotransplantations and to prevent loss of islet mass, which will dramatically impact millions of patients in need of pancreatic islet transplantation. More recently, he has begun to work on surface modifications using functional polymers for medical implants and devices. Applications include chemical modifications for the surfaces where non-fouling is preferred and for the surfaces where tissue integration is required.
Dr. Xie joined the faculty of Department of Biomedical Engineering at IUPUI in August, 2004. Prior to that, he was a faculty member in Department of Biomedical Engineering at University of Alabama at Birmingham for approximately four years after he completed his postdoctoral training with Distinguished Scientist and Professor Jimmy Mays in Department of Chemistry. He received his Ph. D. at Ohio State University in 1998. He had over 80 peer-reviewed publications and over 60 presentations in national and international conferences. He was principal investigator for prestigious NIH challenge grant (RC1 DE020614), principal investigator for NIDCR/NIH funded project (R21 DE018333), principal investigator for NIBIB/NIH funded project (R01 EB003162), and co-principal investigator for NSF funded three campus project (EPS-0083128),
Laboratory research and experimental methodologies
1. Synthesis and characterization of functional oligomers and polymers
- ATRP, RAFT, Free-radical polymerization
2. Formulation and evaluation of synthesized polymers, composites and surfaces
- Strength testing, toughness, hardness, bonding, SEM evaluation
- Surface characterization and evaluation
3. Biocompatibility test
- In vitro cell culture studies and in vivo studies using animal models
Xie, D., Weng, Y., Guo, X., Zhao, J., Gregory, R.L., Zheng, C. Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions, Dent. Mater., 2011; 27:487-496.
Zhao, J., Xie, D. A novel hyperbranched poly(acrylic acid) for improved resin-modified glass-ionomer restoratives, Dent. Mater., 2011; 27:478-486.
Weng, Y, Guo, X, Gregory, R.L., Xie D. A novel antibacterial glass-ionomer cement, Eur. J. Oral Sci., 2010; 118:531-534.
Zhao, J., Weng, Y., Xie, D. In vitro wear and fracture toughness of an experimental light-cured glass-ionomer cement, Dent. Mater., 2009; 25:526-534.
Xie, D., Zhao, J., Weng, Y., Park, J.-G., Jiang, H., Platt, J.A. Bioactive glass-ionomer cement with potential therapeutic function to dentin capping mineralization, Eur. J. Oral Sci., 2008; 116:479-487.
Xie, D., Yang, Y., Zhao, J., Park, J.-G., Zhang, J.-T. A novel comonomer-free light-cured glass-ionomer system for reduced cytotoxicity and enhanced mechanical strength, Dent. Mater., 2007; 23:994-1003.
Xie, D., Park, J.-G., Faddah, M., Zhao, J., Khanijoun, H.K. Novel amino acid-constructed polyalkenoates for dental glass-ionomer restoratives, J. Biomater. Appl., 2006; 21:147-165.
Xie, D., Smyth, C.A., Eckstein, C., Bilbao, G., Mays , J., Eckhoff, D.E., Contreras, J.L. Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation, Biomaterials , 2005; 26(4):403-412 .
Xie, D. , Chung, I-D., Wu, W., Lemons, J., Puckett, A., and Mays, J. An amino acid modified and non-HEMA containing glass-ionomer cement, Biomaterials , 2004; 25(10):1825-1830 .
Xie, D., Feng, F., Chung, I-D., and Eberhardt, A.W. A hybrid zinc-calcium-silicate polyalkenoate bone cement, Biomaterials, 2003; 24(16):2749-2757.