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Purdue School of Engineering and Technology

Purdue School of Engineering and Technology

Cell and Tissue Lab

BME 35400 / 1 Cr.

This course develops quantitative biomechanical methods to analyze cell/tissue behavior and properties to solve biomechanical engineering problems.  Topics include:  bioviscoelasticity, failure, filament dynamics, membrane dynamics, biofluid dynamics, cellular dynamics, and tissue dynamics.

Goals

Through problem sets and bioengineering experiments, introduce students to quantitative methods to analyze cell/tissue behavior and properties.

Outcomes

Upon completion of the course, students will be able to:

  • Determine mechanical forces applied to a cell. [1]
  • Identify and evaluate forces acting on a cell. [1]
  • Model cellular responses to mechanical stimuli. [1]
  • Formulate elasticity and viscosity in a biological system. [1]
  • Formulate mechanics of the cytoskeleton. [1]
  • Determine stress and strain in a tissue level. [1]
  • Use a research-grade microscope for live cell imaging experiments. [6]
  • Conduct experiments and analyze data as a team. [5,6]
Topics
  • Molecular and cellular mechanics
  • Mechanics of the cytoskeleton
  • Stress and strain
  • Bone mechanics: extension and torsion
  • Bone mechanics: bending
  • Molecular engineering experiments
Recommended Reference Books
  • Mechanics of Motor Proteins and the Cytoskeleton by Jonathon Howard (2001), Sinauer Associates, Inc. Publishers (ISBN 978-0-87893-333-4).
  • An Introduction to Biomechanics by Jay D. Humphrey and Sherry L. Delange (2004) Springer-Verlag New York, Inc. (ISBN 0-387-40249-7).