Purdue School of Engineering and Technology

Purdue School of Engineering and Technology

Implantable Materials and Biological Response

BME 38100 / 3 Cr.

BME 38100 combines biomaterials, their biological response, and interactions between implantable materials and biological systems. Materials science of implantable materials; overview of implantable biomaterials and interactions between implants and biosystem; in vitro and in vivo biocompatibility tests; and specific examples on implant-tissue interactions, biocompatibility, and evaluation tools are presented.


Biomaterials: The Intersection of Biology and Materials Science (1st Edition, Pearson), by Temenoff and Mikos (ISBN-13: 978-0-13-009710-1). Janeway’s Immunobiology (8th Edition, Garland Science), by Kenneth Murphy (ISBN 978-0-8153-4243-4) (italicized chapter numbers).


To help students know implantable biomaterials and better understand interactions between the implants and biosystem.


Upon completion of the course, students will be able to:

  • Know basic implantable biomaterials [1]
  • Understand interactions between implantable biomaterials and tissues [1]
  • Know how to select and use basic in vitro and vivo biocompatibility tests to evaluate the tissue response to the implantable biomaterials [1]
  • Know how to characterize the interfaces between the implant and biosystems. [1]
  • Overview of basic materials science
  • Chemical structures and physical properties of implantable materials
    • Metals/Ceramics/Polymers/Composites
    • Biological materials
  • Tissue response to implants
  • Blood and clotting
  • Immunological response
    • Innate immunity
    • Adaptive immunity
  • Degradation of implantable materials
  • Surface properties of implantable materials
    • Protein-material interactions
    • Cell-material interactions
  • Implantable materials processing, characterizations, and sterilization
  • Biocompatibility & Tissue engineering
  • Hypersensitivity
  • Tumorigenesis, transplantation and tolerance
  • Biofilms
  • Wound healing
  • Manipulation of the immune response
Additional Reading Materials
  • Biomaterials Science: An Introduction to Materials in Medicine (2nd Edition, ELSEVIER) by Ratner, Hoffman, Schoen, and Lemons
  • An Introduction to Tissue-Biomaterials Interactions (1st Edition, Wiley-Liss) Dee, Puleo, and Bizios