Purdue School of Engineering and Technology

Purdue School of Engineering and Technology

Models of Musculoskeletal Load

ME 59700 / 3 Cr. (3 Class)

Course content revolves around the effects and interactions of mechanical forces at the cellular and molecular level. The topics will range from describing the molecular and cellular basis of the adaptation of tissues to physical signals, to prescribing specific mechanical environments for improved tissue engineering, to delineating relevant molecular, cellular, and biomechanical techniques, to issues involved in the development and approval of diagnostics and therapeutics in molecular engineering. Course format is based on lectures and discussion of the current literature. For a deeper understanding of the scientific literature, this course will contain a module on the design and statistical analysis of experiments.



After completion of this course, students should be able to:

  • Apply frequently used statistical tools
  • Summarize and synthesizee studies in molecular, cellular and tissue biomechanics
  • Device studies in molecular, ceullular and tissue biomechanics
  • Communicate and critque scientific studies effectively

Topics include (but are not limited to)

  • Introduction to molecular and cellular biomechanics
  • Experimental design and statistical data analysis
  • Scientific writing in molecular and cellular biomechanics
  • Classic mechanics in biology (Intervertebral Disc, Bone & Tendon)
  • Cell mechanics
  • Mechanics of cell locomotion
  • Tensegrity
  • Grant writing
  • Molecular stress responses / mechanotransduction
  • Mechanical signal transduction