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46 results found
Introductory Biomeasurements
BME 22201
Credits: 3
The foundations of basic circuit theory are introduced including voltage-current characteristics of resistive and reactive elements, Ohm's and Kirchhoff's Laws, equivalent sources, transformations and superposition, transient response, instantaneous and average power, AC impedance, dynamic response of first and second order systems.
Biomeasurements Lab
BME 22400
Credits: 1
Laboratory exercises will reinforce the foundations of basic circuit theory. Electronic instruments are used in the context of biomedical signal measurement and processing and include the use of oscilloscopes, function generators, transducers, electrodes, biopotential amplifiers and digital data collection and analysis. Laboratory exercises utilize industrially relevant instruments for measurement and acquisition of time varying signals arising from electronic and bioelectric sources.
Introductory Biomechanics
BME 24101
Credits: 3
This course uses didactic lecture material to introduce students to the principles of mechanics and how these concepts apply to musculoskeletal tissues.
Biomechanics Lab
BME 24300
Credits: 1
Probability and Applications in BME
BME 32200
Credits: 3
Probability theory and statistical methods are developed for life science applications. Analytical tools such as hypothesis testing, estimation of moments, sampling theory, correlation and spectral analysis are developed and applied to identifying underlying processes in biological systems, developing realistic models of physiological processes, designing experiments, and interpreting biological data.
Biosignals and Systems
BME 33100
Credits: 3
This course applies mathematical analysis tools to biological signals and systems. Frequency analysis, Fourier and Laplace transforms, and state equations are used to represent and analyze continuous and discrete-time biosignals. Classic feedback analysis tools are applied to biological systems that rely on negative feedback for control and homeostasis.
Biomedical Computing
BME 33400
Credits: 3
This course explores computational approaches to analyzing biological data and solving biological problems. Students will fit and interpret biological data, apply probabilistic and differential equation modeling techniques to biological processes, and assess numerical tools for biomedical applications. Special attention is given to the built-in analysis functions of MATLAB.
Cell and Tissue Mechanics
BME 35200
Credits: 3
This course will introduce the students to the biological principles of cellular/tissue behaviors and properties. Topics include: fundamental concepts of cellular structure and tissue organization, biomolecular elements and their properties, cell shape, cell adhesion and migration, mechanotransduction, pattern formation in embryos, and stem cell and tissue regeneration.
Cell and Tissue Lab
BME 35400
Credits: 1
This course develops quantitative biomechanical methods to analyze cell/tissue behavior and properties to solve biomechanical engineering problems. Topics include: bioviscoelasticity, failure, filament dynamics, membrane dynamics, biofluid dynamics, cellular dynamics, and tissue dynamics.
Implantable Materials and Biological Response
BME 38100
Credits: 3
This course combines biomaterials, their biological response, and interactions between implantable materials and biological systems. Materials science of implantable materials; overview of implantable biomaterials and interactions between implants and biosystems; in vitro and in vivo biocompatibility tests; and specific examples on implant-tissue interactions, biocompatibility, and evaluation tools are presented.
Implantable Materials Lab
BME 38300
Credits: 1
BME 38300 is a corequisite course to BME 38100, supplementing the basic science of BME 38100 with quantitative, analytical examples and problems related to fundamental engineering principles in implantable materials. Topics include: microstructure, phase transformation, processing and design issues related to major engineering materials used for implantation purposes.
Applied Biomaterials
BME 38800
Credits: 3
This course covers foundational knowledge in the fields of materials science and engineering. Emphasis is placed on the materials used in biomedical applications and the relationship between material properties and the performance of these biomaterials.
Senior Seminar
BME 40200
Credits: 1
BME 40200 explores career and professional topics in Biomedical Engineering. Topics include resume writing, interviewing, and professional conduct; post-graduate education and life-long learning; and industrial, clinical, and research opportunities in Biomedical Engineering.
Quantitative Physiology in BME
BME 41101
Credits: 4
This course is an introductory course in physiological systems and an introductory course in classical feedback control theory for biomedical engineers. It aims to apply systems theory and classical feedforward and feedback control in the context of physiological. Control, frequency response, and linear systems concepts are applied to action potential generation, motor control, heart rate regulation, and other physiological processes. Approximately a third of the course will be devoted to physiological systems, as third to classical control theory and a third to the application of classical control and systems theory to physiological systems.
Biofluid Mechanics
BME 44200
Credits: 3
This course explores fluid mechanics in the context of the human circulatory system. Principal equations are derived from differential analysis of fluid flow, and models of characteristic flow conditions are fully analyzed. Biofluid mechanics, vessel biomechanics, and hemodynamic analysis of the circulation system will also be discussed.
Transport Processes in BME
BME 46100
Credits: 3
This course explores engineering principles in mass and other transport processes in biological systems. Topics covered include diffusion, convection, reaction kinetics, transport in porous and fluid mediums, etc. Mathematical models of transport are developed and applied to biomedical problems and physiological systems such as the kidney/renal and oxygen/arterial systems.
Biomedical Engineering Design I
BME 49101
Credits: 2
BME 49101 prepares students for engineering practice through a major design experience, encompassing conceptualization, requirements generation, and system and detailed design. Essential design constraints will be reviewed and applied including: safety, economic, and manufacturability. The course encompasses lectures, case studies, team formation, project assignments and generation of initial design.
Biomedical Engineering Design II
BME 49200
Credits: 3
This course continues the design experience from BME 49101 with verification, validation, and re-design of student projects. Regulatory and ethical design constraints will be discussed. Oral presentation and report writing are required.
Tissue Engineering
BME 49500
Credits: 3
This is a senior undergraduate level Tissue Engineering class that focuses on the basic principles of tissue engineering, including cell sources, influence of soluble and immobilized cues in tissue morphogenesis, matrix/scaffold preparation and characterizations, as well as the integration of the abovementioned components for the goal of assisting tissue regeneration, replacing lost tissues, or restoring tissue functions.
BME Graduate Seminar
BME 50000
Credits: 0
Implantable Systems
BME 52700
Credits: 3
Engineering constraints surrounding the selection of a power source for an implantable system and in particular how the control of the target organ system impacts power plant design. The organ specific design of cochlear neuroprosthetics, functional neuromuscular stimulation systems and cardiac pacemakers are presented in detail as but three examples of technically mature implantable systems that have had broad clinical impact. For each, there is a brief introduction to the related anatomy, physiology and neurophysiology of the target organ system so that students may gain perspective on the functional limits of the artificial control of these organ systems. Several implantable systems presently in the early stages of bioengineering design or in the early stages of clinical trials are presented as state-of-the-art examples. Particular attention is given to practical bioengineering issues related to the ever expanding use of implantable biomedical sensors in order to provide real-time control of the implant and improved response to challenges to the homeostasis of organ system function. Issues related to ethical and regulatory considerations related to implantable system design including animal testing, human clinical trials and FDA premarket approval are also introduced.
Experimental Methods in Biomedical Engineering
BME 53700
Credits: 3
The course begins with the basic principles of hypothesis formulation and testing. Lectures rapidly progress toward the statistical design of experiments and proper selection of laboratory instrumentation, techniques and methodologies for testing a particular hypothesis, i.e. all experimental instrumentation and methodologies impart limits upon data interpretation relative to the specific biological questions understudy. Practical examples are derived from areas of neuroscience and cardiovascular research and involve a diverse range of instrumentation and methodologies including in vivo, in situ and in vitro electrophysiology (intra and extracellular recordings, care and use of animals, etc.), microscopy (optical, confocal, electron etc.) and fluorescent indicators (lipophilic dyes, antibody labeling, etc.) along with basic principles of noncontact in vivo imagining at the level of organ systems and cellular networks. Class time will also be devoted to development of experimental protocols that involve animal and human subjects, biosafety issues and the review processes for protocol submission.
Musculoskeletal Biology and Mechanics
BME 54400
Credits: 3
This course will cover topics relevant to skeletal biology including skeletal morphology, physiology, cell biology, embryonic development, adult osteogenesis, mineral homeostasis, tissue mechanics, mechanical adaptation, failure (fracture), fracture fixation, implants, implant mechanics and disease dynamics.
Drug Delivery
BME 57100
Credits: 3
This course will explore the principles, techniques, and applications for therapeutic drug delivery and administration. This course will start with the fundamentals of drug administration: engineering principles such as diffusion and mass transport, with specific emphasis on transport in biological systems and barriers, pharmacokinetics, and drug distribution. We will examine the existing state of art in drug delivery systems: controlled release, biomaterials, and polymer-based delivery systems. Finally, we will also discuss the current field of biotechnology and biopharmaceuticals: identification of novel drug targets, latest development in drug discovery, development, clinical trials, and product development, going from research to market using the latest examples from the pharmaceutical industry.
Advanced Biomedical Polymers
BME 58200
Credits: 3
This is an advanced polymer course that provides the most recent development of biomedical polymers and their applications and covers a variety of biomedical areas such as in cardiovascular, dental, orthopedic, ophthalmologic and wound healing research. Drug, cellular and gene delivery are also covered. This course is designed for all the senior undergraduate and graduate students (M.S. and Ph.D. level) in biomedical areas. Except for learning, students are also required to discuss the related topics and write term papers related to the assigned special topics in the class.
Vascular Biomechanics
BME 59500
Credits: 3
This course will cover the mathematical preliminaries and theoretical framework to analyze the mechanics of soft biological tissues. Emphasis is placed on the application of continuum mechanics to the study of the arteries; the measurement and quantification of material properties and the calculation of vascular stresses.
Biomedical Ultrasound Imaging
BME 59500
Credits: 3
Falll 2023
Ultrasound imaging is one of the most widely used medical imaging modality in the world. This course will present the physical basis for using high-frequency sound in medicine. We will explore ultrasound instrumentation, transducers, and the physical principles of sound waves/ultrasound propagating in tissue. Such topics will include the wave equation, acoustic impedance, reflection and transmission of sound, refraction, basic signal processing, sound beams, transducers, ultrasound attenuation, and scattering. The latter part of the course will heavily emphasize medical ultrasound. Students will construct a tissue-mimicking phantom, acquire ultrasound images, and then work through image post-processing on their data. Finally, we will discuss emerging ultrasound technologies in industry and clinics, including bubble dynamics and drug delivery, lithotripsy, and high-intensity focused ultrasound for thermal ablation. Students will learn via lectures, homework, in-class lab exercises, and a final project to gain knowledge, retain the ability to think critically, and develop problem-solving skills through medical imaging.
Biomolecular Engineering
BME 59500
Credits: 3
This course covers the experimental and computational tools useful to analyze biological molecules and molecular systems, potential applications of DNA/protein molecules for designing nano-scale motors, switches, and computers. The topics include electrophoresis, genome-wide molecular analysis, network analysis, DNA manipulations, protein interactions, and microfluidics.
Biosignal Processing Laboratory
BME 59500
Credits: 3
This is laboratory based course which cover several biosignal processing problems. These would include the origin and biophysics of biosignals; noise, interference and simple digital filtering; adaptive filters and signal averaging; correlation and spectrum estimation; data compression; orthogonal expansion techniques.
Embedded Bioinstrumentation
BME 59500
Credits: 3
The advent of the current generation of low cost, low power, electronically programmable embedded systems has enabled the development of a new generation of portable medical bioinstrumentation. However, implementation of such devices requires the integration of analog interfaces, analog to digital/digital to analog signal conversion, digital filtering and programming in the medical devices arena. These topics will be reinforced through the development of a embedded TI-MSP430 based biomedical device.
Advanced Tissue Engineering
BME 59500
Credits: 3
This course will cover biological principles and physiological phenomena underlying cellular regulation during development, homeostasis, and wound healing. Topics also include tissue engineering fundamentals, such as cell sources, transplantation immunology, processing of scaffolding materials, integration at cell-material interfaces, mechanisms of incorporation and release of biologics, engineered culture environments, and host-transplant integration. Students will have opportunity to evaluate clinically relevant tissue engineering products and cutting-edge tissue engineering research.
Polymers for Biomedical Applications
BME 59500
Credits: 3
This course describes basic synthesis, characterization and applications of current synthetic and natural biocompatible polymers. This course is designed for undergraduate and graduate students in all areas who are interested in biomedical polymers, since polymers currently are so popular in biomedical, pharmaceutical and tissue engineering research. Topics include: overview of basic materials science, organic chemistry and biochemistry, introduction to polymers, biodegradable polymers, and polymeric hydrogels.
Neural Engineering
BME 59500
Credits: 3
Neural engineering is an emerging engineering discipline that combines the various disciplines of engineering with the biological, physical and material sciences to find the means to access, understand, manipulate, and perhaps enhance the nervous system and the information it contains. The aim of this course is to provide an introduction to the field of neural engineering and will start with the introduction of the neuron, the bioelectric phenomenon and the neural / electronic interface. These topics will be reinforced through hands on practical experiments using electrodes for stimulation and recording.
Cellular Electrophysiology
BME 59500
Credits: 3
This course provides both the theoretical and practical training necessary to understand the operational principles of voltage and current clamp instrumentation most often used in cellular neurophysiology. The application and capabilities of the instrumentation are presented relative to the fundamental principles of bioelectricity most often studied in cellular electrophysiological research including: current, voltage, charge, resistance, capacitance, impedance relative to the phospholipid bilayer and protein pore, elementary properties of ions in solution, the Nernst-Plank equation, subthreshold membrane phenomena, space clamp of membrane potential, electrotonic considerations, conduction of action potentials along axons and spread of membrane potential throughout cell body and dendrites. Additional topics include the origin and analysis of extracellular biopotentials. Course lectures progress from the practical aspects of extracellular recording techniques through to understanding fundamental principles of volume conduction and the effects these have upon the recorded biopotential signals. The course closes with the study of advanced topics of bioelectric phenomena including elementary field theory, the core conductor and lumped fiber source models.
Molecular and Cellular Mechanics
BME 59500
Credits: 3
This course is aimed at understanding the mechanical designs of cells with emphasis on the dynamics of cellular components such as biopolymers (DNA and proteins), two-dimensional and three-dimensional filament networks, and lipid membranes. The topics include entropic consideration and persistence length of biopolymers, energy distributions in network structures, dynamics of filaments and motor proteins, membrane stability and undulations, integration of cellular components, and mechanical design of cells.
Cardiac Electrophysiology
BME 59500
Credits: 3
This course will introduce the basic principles of cardiac generated bioelectricity and will be examined at the cellular, extracellular, and body surface levels. The generation of abnormal cardiac rhythms and the relevant electro-therapies will be emphasized. These include the principles of cardiac pacemakers and defibrillators as well as the tools used in cardiac ablation therapy, e.g., cardiac mapping and ablative energy sources. Modern signal processing methods applied to electrocardiography will also be presented.
Engineering Principles of Biotechnology
BME 59500
Credits: 3
This course will explore the engineering principles behind advanced biomedical technologies and modern biotechnology. This course will examine in depth the engineering fundamentals used in the development of modern biotechnology. More specifically, we will discuss engineering and mathematical fundamentals used in microbial fermentations, enzyme kinetics, biological thermodynamics, genetic and recombinant engineering, and the production of monoclonal antibodies, and other biopharmaceuticals. Topics to be covered include: bioproducts and biofules, microbial fermentation and bioreactors, mathematical modeling and simulations of biological processes, enzyme kinetics, metabolic pathways and genetic engineering.
Cellular Mechanotransduction
BME 59500
Credits: 3
This course will cover the biochemical signaling in response to various mechanical stresses in the context of physiology and pathophysiology. Topics include the behavior of live cells during cell motility, force generation, and interaction with the extracellular matrix; the advanced biomechanical testing tools used for in vitro characterization of living cells; mechanotransduction that converts mechanical forces into biochemical signaling.
Engineering Principles of Biomolecular Interaction
BME 59500
Credits: 3
This course will introduce principles of thermodynamics, physical chemistry, and reaction kinetics in the context of biomolecular recognition. Advanced topics include principles and techniques to manipulate receptor-ligand recognition processes and cell-biomaterials interactions, as well as design and delivery of biomolecular and cellular therapeutics for disease treatment.
Engineering Analysis of Tissues
BME 59500
Credits: 3
This course will cover the principles of a number of characterization methods used to assess the quantity and quality of tissues. These will include, but are not limited to: Atomic force microscopy, Indentation, mechanical testing (static and dynamic), Raman/FTIR, EM, Fluorescence, CT, Backscatter EM.
Advanced Biomolecular Engineering
BME 69500
Credits: 3
One of the most challenging tasks for the current biomedical engineers is to extract biologically important information from a large amount of data such as genomic DNA sequences and mRNA/protein expression data. Using examples in human genomics and proteomics, this course describes cutting-edge biomolecular technologies, computational algorithms, and mathematical models. The first half is genomics focusing on experimental designs with microarrays and analyses of microarray-derived data, and the second half is proteomics focusing on the principles of mass spectrometry and analyses of protein expression data. The subjects include structure of human genome, DNA microarrays, cluster analyses, singular value decomposition, modeling and voting, mass spectroscopy, protein arrays, systems biology, and biostatistics.
Advanced Biomedical Engineering Topics
BME 69600
Credits: 1-6
Individual research projects to be approved by the supervising faculty member before registering for the course. An approved written report is required.
Directed Readings in Biomedical Engineering
BME 69700
Credits: 1-3
Individualized reading course supervised by an appropriate faculty member. Approval for each reading course must be obtained from the department prior to registration.